Sam Altman of Y Combinator: “We Want To Hire More St. Louis Startups.”

Y Combinator, one of the most prestigious startup incubators in the world, wants to invest in more St. Louis startups. That’s according to the Silicon Valley incubator’s president, Sam Altman, who participated in several Q&A sessions Thursday at the Washington University School of Engineering and Applied Science.

Sam Altman
WUSTL’s Dedric Carter speaking with Sam Altman on stage Thursday night at the Washington University School of Engineering and Applied Science.

Altman, a native St. Louisan, offered tips to a packed auditorium about how to succeed as an entrepreneur and answered questions about his experience guiding hundreds of startups through YC since he became president in 2012. YC’s graduates have a combined valuation of more than $65 billion and include the likes of Airbnb, Reddit and Dropbox.

Altman was joined onstage during a portion of the event by David Messina, chief operating officer of Cofactor Genomics, which YC started backing in 2015. The St. Louis-based biotech company uses RNA sequencing to test for diseases.

After the event, Altman admitted to reporters that one purpose of the visit was recruitment. “We want to hire more St. Louis startups,” he said. Altman met with several St. Louis startups earlier in the day and says he plans to talk to at least two of them about coming to YC.

The company selects two batches of startups for its main three-month program. Altman said nearly 25,000 companies from around the world applied last year. Only 107 startups were accepted into its fall 2015 class.

EQ spoke with Altman about the future of biotech in St. Louis, the roles of accelerators in emerging markets and whether he’s considered starting a venture in his hometown. Below are excerpts.

YC has funded dozens of biotech startups in the past couple years, including Cofactor Genomics, which started in STL. What do you think the future looks like for biotech startups? And what might that mean for a place like St. Louis, with its research universities, biotech incubators, accelerators and corporate ties?

There were a lot of things I was impressed with today, but the single thing that I was most impressed with was the quality of the biotech companies and just how much of an ecosystem there is here. I met with nine of them individually this afternoon, and I got to spend some time at Cortex today.

It feels like there really is a center of gravity here around that, honestly, you don’t even really see in the Bay Area, just in terms of the density of it and people working on really good things. So I think [biotech] is clearly a giant market.

I think it’s possible for startups to be a great biotech company in the past few years in a way that it wasn’t before. When we look at new industries, what we look at is the cost and the cycle time.

Startups are always capital constrained, and so if costs are high, it’s hard to win against a big company. The advantage of startups is moving quickly, and if cycle time is really high, if it takes longer to iterate, then it’s harder.

If it’s short, then you have a real advantage. I think that’s really shifted for biotech companies, and this is a great time to start one. And it does feel like St. Louis really does have something special going there.

YC is such a large, accelerator that has a broad reach across industries. What role can smaller, niche-industry accelerators that focus on say, AgTech (The Yield Lab) or Sports Business-focused (Stadia Ventures), play?

There are two things you need with a startup. You need advice about how to be a good startup in general, and you need already to know or need advice about the specific thing you’re building.

So I think these sort of narrow accelerators can give extremely good advice in a particular vertical about how to sell to farmers, for that example.

What role do you feel that accelerators play in building a community and a density of startups in a city?

It’s a great question. I don’t feel like I can answer this with a lot of certainty because by the time YC existed, Silicon Valley already had a lot of startups so the community would have already been there without us.

But I do think I’ve seen in other cities how an accelerator forms the center-of-gravity of a startup ecosystem. It’s so important for startup founders to have peers because it’s a lonely and hard job.

And it’s also so important to have a broader community of some successful startups that get acquired, and then the employees there have money, and they use that to invest in other startups. And I do think accelerators can be the center of gravity around which this forms.

What do you think about fellow St. Louis natives Jack Dorsey and Jim McKelvey bringing projects like Square back to their hometown? Is that something you’ve ever had any ambitions for, to bring something back to St. Louis?

Yeah, but no specific plans. Specifically for YC, we’ve made the decision that, at least for now, not to go open other offices.

We think the mistake that many startups make is to go open multiple offices instead of having everyone together in one place. We do try to follow our own advice, and our own advice is that we do all want to be together.

We want to have one organization. And Silicon Valley is still an incredible place to start companies.

We have a strong network there. So, I think though I’m unfortunately not looking to open YC St. Louis this year, but it would be fun to figure out how to do something here at some point.

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